364360-75-8

Upstream product

• 108-24-7 acetic anhydride 
• 364360-76-9 3-amino-6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 824-94-2 p-methoxybenzyl chloride 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 
• 253668-48-3 2-Bromo-N-[4-chloro-2-(2,2,2-trifluoro-acetyl)-phenyl]-acetamide 
• 253663-53-5 6-chloro-4-(cyclopropylethynyl)-3,4-dihydro-4-(trifluoromethyl)-2(1H)-quinolinone 
• 253663-85-3 3-benzenesulfonyl-6-chloro-4-trifluoromethyl-1H-quinolin-2-one 
• 253663-82-0 3-benzenesulfonyl-6-chloro-4-hydroxy-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 253663-87-5 3-benzenesulfonyl-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 364360-77-0 6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 364360-40-7 3-azido-6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 

Relevant academic research and scientific papers

Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.