364595-09-5

Upstream product

• 1486-50-6 4-(benzyloxy)benzoic acid chloride 
• 1219626-47-7 (Z)-N',4-dihydroxybenzimidamide 
• 55667-07-7 3,5-bis(4-methoxyphenyl)-1,2,4-oxadiazole 

Downstream Products

• 1397693-04-7 3,5-bis{4-[5-(4'-cyanobiphenyl-4-yloxy)pentanoyloxy]phenyl}-1,2,4-oxadiazole 
• 1397693-03-6 3,5-bis{4-[4-(4'-cyanobiphenyl-4-yloxy)butanoyloxy]phenyl}-1,2,4-oxadiazole 
• 1613754-10-1 C₄₈H₅₈N₂O₇ 
• 1613754-07-6 C₄₂H₅₀N₂O₃ 
• 1613754-02-1 C₅₂H₆₆N₂O₉ 
• 1613754-04-3 C₈₈H₁₃₈N₂O₁₁ 
• 1613754-03-2 C₆₈H₉₈N₂O₉ 
• 1613754-01-0 C₄₄H₅₀N₂O₉ 

Relevant academic research and scientific papers

Banana-shaped 1,2,4-oxadiazole analogues of 1,3,4-oxadiazoles

In the last years bent banana-shaped mesomorphic molecules found an increasingly great interest among theoreticians and experimentalists due to the nature of this type of liquid crystals to exhibit a spontaneous polarization in the absence of any chiral g

Structure-Activity Relationship for the Oxadiazole Class of Antibacterials

A structure-activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro toxicity, plasma protein binding, pharmacokinetics (PK), and a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Oxadiazole 72c shows potent in vitro antibacterial activity, exhibits low clearance, a high volume of distribution, and 41% oral bioavailability, and shows efficacy in mouse models of MRSA infection.