364628-26-2Relevant academic research and scientific papers
Discovery of cyclicsulfonamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors
Kim, Se Hoan,Ramu, Ravirala,Kwon, Sung Wook,Lee, Su-Hee,Kim, Chi Hyun,Kang, Seung Kyu,Rhee, Sang Dal,Bae, Myung Ae,Ahn, Sung Hoon,Ha, Duck Chan,Cheon, Hyae Gyeong,Kim, Ki Young,Ahn, Jin Hee
supporting information; experimental part, p. 1065 - 1069 (2010/06/14)
A new series of cyclic sulfonamide derivatives was synthesized and evaluated for their ability to inhibit 11β-HSD1. Cyclic sulfonamides with phenylacetyl substituents at the 2-position showed nanomolar inhibitory activities. Among them, compound 4e exhibited a good in vitro inhibitory activity and selectivity toward human 11β-HSD2.
