364635-80-3 Usage
Molecular Structure
Contains a 15-membered ring with four nitrogen atoms
Functional Groups
Hydroxyl group
Methyl group
Phenyl group
Esterification
Formed as a t-butyl ester, indicating the presence of a t-butyl group
Stereochemistry
(3S,6S,7S,9R,12S) designation denotes the arrangement of substituents around chiral centers
Applications
Potential applications in medicinal chemistry and drug development due to its unique structure and functional groups
Check Digit Verification of cas no
The CAS Registry Mumber 364635-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,4,6,3 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 364635-80:
(8*3)+(7*6)+(6*4)+(5*6)+(4*3)+(3*5)+(2*8)+(1*0)=163
163 % 10 = 3
So 364635-80-3 is a valid CAS Registry Number.
364635-80-3Relevant academic research and scientific papers
Structure-based design: Potent inhibitors of human brain memapsin 2 (β-secretase)
Ghosh,Bilcer,Harwood,Kawahama,Shin,Hussain,Hong,Loy,Nguyen,Koelsch,Ermolieff,Tang
, p. 2865 - 2868 (2007/10/03)
Memapsin 2 (β-secretase) is one of two proteases that cleave the β-amyloid precursor protein (APP) to produce the 40-42 residue amyloid-β peptide (Aβ) in the human brain, a key event in the progression of Alzheimer's disease. On the basis of the X-ray crystal structure of our lead inhibitor (2, OM99-2 with eight residues) bound to memapsin, we have reduced the molecular weight and designed potent memapsin inhibitors. Structure-based design and preliminary structure-activity studies have been presented.
