36467-68-2 Usage
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 36467-68-2 differently. You can refer to the following data:
1. Elicits plant defense systems.
carbohydrate component of lipo-chitooligosaccharides secreted by Rhizobia, functioning as a signaling molecule in the host plant.
substrate for Rhizobium leguminosarum nodulation protein NodL.
Root nodules, like those induced on the roots of leguminous plants by Rhizobium bacteria, are important sites for the conversion of atmospheric nitrogen into ammonia. The initiation and development of these growths are driven by a variety of nodulation (Nod) proteins produced by the infecting bacteria. Penta-N-acetylchitopentaose is a pentameric chito-oligosaccharide involved in nodulation. It can be produced by NodC, a chito-oligosaccharide synthase, and serve as a substrate for NodL, an O-acetyltransferase.This bacterial product binds plant root lectins, and this interaction may be important in the promotion of cell division in the root cortex.Penta-N-acetylchitopentaose, as well as chitin and chitosan, inhibits nitric oxide production in LPS-activated RAW 264.7 macrophages.
2. Studies have shown this compound to have anti tumor effects.
Production Methods
Cell density cultivation of recombinant Escherichia coli strains harboring the nodC gene (encoding chitooligosaccharide synthase) from Azorhizobium caulinodans has been previously described as a practical method for the preparation of gram-scale quantities of penta-N-acetyl-chitopentaose. We have now extended this method to the production of allylated derivative of penta-N-acetyl-chitopentaose by using allyl 2-acetamido-2-deoxy-β-d- glucopyranoside (2) as the initial acceptor for the synthesis of target pentaoside in vivo.
Chemo-enzymatic synthesis of allyl penta-N-acetyl-chitopentaose
Huang, Gang-Liang; Zhang, Da-Wei; Zhao, Hong-Juan; Zhang, Hou-Cheng; Wang, Peng-George - Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 2042 - 2043
Check Digit Verification of cas no
The CAS Registry Mumber 36467-68-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,4,6 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 36467-68:
(7*3)+(6*6)+(5*4)+(4*6)+(3*7)+(2*6)+(1*8)=142
142 % 10 = 2
So 36467-68-2 is a valid CAS Registry Number.
36467-68-2Relevant articles and documents
Concise preparation of biologically active chitooligosaccharides
Huang
experimental part, p. 1413 - 1417 (2010/12/19)
Chitooligosaccharides (COSs) have demonstrated a diverse array of biological activities. Here we report a concise preparation method for tetra-N-acetyl-chitotetraose and penta-N-acetyl-chitopentaose. The FACE analysis showed that the partially N-acetylated COS mixture mainly contained glucosamine (GlcN) and some oligomers [(GlcN)n, n = 2-7]. The N-acetyl-D-glucosamine (GlcNAc) and peracetylated COSs [(GlcNAc)n, n = 2-7] were synthesised by treating the partially N-acetylated COS mixture with Ac2O-NaOAc. The peracetylated chitotetraose and chitopentaose were obtained by isolation of peracetylated COS mixture. NaOMe in dry MeOH was used for the deacetylation of peracetylated chitotetraose and chitopentaose, to give the tetra-N-acetyl- chitotetraose and penta-N-acetyl-chitopentaose, respectively.
