3647-48-1

Basic information

• Product Name: 6-AMINO-2-MERCAPTOPURINE
• Synonyms: 2-mercaptoadenine;2-thioadenine;6-amino-1,3-dihydro-2h-purine-2-thion;6-amino-purine-2-thio;6-AMINO-2-MERCAPTOPURINE;6-Amino-1,7-dihydro-2H-purine-2-thione;6-Amino-2-mercapto-9H-purine;6-Amino-7H-purine-2-thiol
• CAS NO: 3647-48-1
• Molecular Formula: C₅H₅N₅S
• Molecular Weight: 167.19
• Mol File: 3647-48-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 273.3°Cat760mmHg
• Flash Point: 119.1°C
• Appearance: /
• Density: 2.08g/cm³
• Vapor Pressure: 0.000373mmHg at 25°C
• Refractive Index: 2.07
• PKA: 5.81±0.40(Predicted)
• CAS DataBase Reference: 6-AMINO-2-MERCAPTOPURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2-MERCAPTOPURINE(3647-48-1)
• EPA Substance Registry System: 6-AMINO-2-MERCAPTOPURINE(3647-48-1)

Safety Data

• Hazardous Substances Data: 3647-48-1(Hazardous Substances Data)

Usage

Uses

6-?Amino-?7H-?purine-?2-?thiol is a reagent in the preparation of alkylated heterocyclic bases.

InChI:InChI=1/C5H5N5S/c6-3-2-4(8-1-7-2)10-5(11)9-3/h1-2H,(H3,6,7,8,9,10,11)

Upstream product

• 753502-74-8 N-(4,6-diamino-2-thioxo-1,2-dihydro-pyrimidin-5-yl)-formamide 
• 77287-34-4 formamide 
• 1073-99-0 4,5,6-triamino-2-mercapto-pyrimidine 

Downstream Products

• 73-24-5 7H-purin-6-ylamine 
• 68-94-0 1,7-dihydro-6H-purin-6-one 
• 43003-87-8 3-ethyl-3H-purin-6-ylamine 
• 28128-25-8 2-bromo-9H-purin-6-amine 

Relevant articles and documents

Method for synthesis of adenine (by machine translation)

The invention discloses a synthetic method for adenine. Malononitrile and thiourea are employed as raw materials. The raw materials are subjected to a cyclization reaction under action of sodium alkoxide, and 4,6-diamino-2-sulfydryl pyrimidine. Then through three reaction routes, adenine is obtained. Though the method has many reaction steps, no refining or drying are needed for the product of each reaction step, the product can be used in the next reaction step, and the operation is simple. The raw materials are easily available, the prices are relatively low, the reaction conditions are mild, the operation is simple, the reaction steps are decreased, the reaction time is shortened, the overall reaction yield is high, and the synthetic method is suitable for industrial production.

PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY

A compound of the formula: wherein R2 is O or S; R3, R6a and R8 are the same or different and each represent a C1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, alkoxy, CO2H, =NOH, =NOCONH2, or =O; C3-8 cycloalkyl which is unsubstituted or substituted with OH, alkoxy, CO2H, =NOH, =NOCONH2, or =O; C4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, alkoxy, CO2H, =NOH, =NOCONH2, or =O; aryl which is unsubstituted or substituted with Cl, NH2, alkylamino, dialkylamino, amido, C1-C8 alkylamido, C1-C3 dialkylamido, OH, alkoxy, HC=NOH, HC=NOCONH2, C1-C3 alkyl, phenyl or benzyl; aralkyl (C1-4); heterocyclyl; heterocyclylalkyl (C1-C4); and heteroaryl; R6b represents a H or R6a, or together R6b, N, and R6a make a 3 to 8 member ring containing at least one carbon, from one to three nitrogen atoms, from zero to two oxygen atoms, from zero to two sulfur atoms, said ring optionally substituted with alkoxy, CO2H, CONH2, =NOH, =NOCONH2, =O; and where aryl is phenyl or naphthyl, the heterocyclyl is a 5, 6 or 7 membered ring including from one to three nitrogen atoms, and from zero to two oxygen atoms, from zero to two sulfur atoms, and can be substituted as in aryl on the carbons or nitrogens of that ring; or a pharmaceutically acceptable salt thereof, provided that when R3 is propyl, R8 is not cyclopentyl, noradamantyl, or dicyclopropylmethyl.