364776-75-0

Basic information

• Product Name: 5'-O-[(2-cyano-2-phenylethoxy)carbonyl]thymidine
• Synonyms: 5'-O-[(2-cyano-2-phenylethoxy)carbonyl]thymidine
• CAS NO: 364776-75-0
• Molecular Weight: 415.403
• Mol File: 364776-75-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-O-[(2-cyano-2-phenylethoxy)carbonyl]thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-[(2-cyano-2-phenylethoxy)carbonyl]thymidine(364776-75-0)
• EPA Substance Registry System: 5'-O-[(2-cyano-2-phenylethoxy)carbonyl]thymidine(364776-75-0)

Safety Data

• Hazardous Substances Data: 364776-75-0(Hazardous Substances Data)

Upstream product

• 52923-48-5 3-hydroxy-2-phenylpropanenitrile 
• 50-89-5 thymidine 

Downstream Products

• 50-89-5 thymidine 

Relevant articles and documents

Nucleosides. Part LXIV. Base-Labile Protecting Groups for the Oligoribonucleotide Synthesis

New labile protecting groups for the anticipated synthesis of oligoribonucleotides were developed and introduced via their carbonochloridates 8-11 at the 5'-O position of thymidine (15) to form 16, 18, 21, and 24 in good yields (Schemes 2 and 3). Similarly, the 5'-O-diphenylphosphinoyl(dpp)-protected thymidine derivative 27 was synthesized with diphenylphosphinoyl chloride 14 as the reactive reagent. With the help of the model compounds 16, 18, 21, 24, and 27, the deprotection rates of these functions towards base treatment were recorded to evaluate their usefulness as temporary protecting groups in RNA assembly (Table). Finally, the relative stability of the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) protecting group towards bases confirmed its use as a permanent blocking group in our npe/npeoc strategy.