364793-65-7

Basic information

• Product Name: 7-iodo-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• Synonyms: 7-Iod-4-oxo-1,4-dihydrochinolin-3-carbonitril
• CAS NO: 364793-65-7
• Molecular Formula: C₁₀H₅IN₂O
• Molecular Weight: 296.064
• Mol File: 364793-65-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 372.767°C at 760 mmHg
• Flash Point: 179.243°C
• Density: 1.999g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.737
• CAS DataBase Reference: 7-iodo-4-oxo-1,4-dihydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 7-iodo-4-oxo-1,4-dihydroquinoline-3-carbonitrile(364793-65-7)
• EPA Substance Registry System: 7-iodo-4-oxo-1,4-dihydroquinoline-3-carbonitrile(364793-65-7)

Safety Data

• Hazardous Substances Data: 364793-65-7(Hazardous Substances Data)

Upstream product

• 20776-54-9 2-amino-4-iodobenzoic acid 
• 116529-62-5 4-iodo-2-nitro benzoic acid 
• 41252-97-5 4-iodo-2-nitrotoluene 
• 75-05-8 acetonitrile 
• 364793-63-5 (E)-2-Cyano-3-(3-iodo-phenylamino)-acrylic acid ethyl ester 
• 626-01-7 3-Iodoaniline 

Downstream Products

• 364793-64-6 4-chloro-7-iodo-3-quinolinecarbonitrile 

Relevant articles and documents

Novel quinazoline-containing compound, and intermediate and application thereof

The present invention discloses a quinazoline-containing compound having the formula (IA), (IB) or (IC), or a pharmaceutically acceptable salt or a prodrug molecule thereof. The compound is suitable for use as an Aurora kinase inhibitor and is thus suitable for the treatment of Aurora-mediated diseases characterized by excessive or abnormal cell proliferation, for example, cancer.

Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles.

Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed.