36508-71-1 Usage
Originator
Zorubicin
Hydrochloride,ZYF Pharm
Chemical
Uses
Different sources of media describe the Uses of 36508-71-1 differently. You can refer to the following data:
1. Antineoplastic.
2. Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500).
Manufacturing Process
9.024 g daunorubicin-hydrochloride (its preparation and physicochemical
properties have been described in British Patent Specification No 985 598)
was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162
g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained
precipitate was filtered off, washed with 100 ml of ethanol and dried in
vacuum at 20°C. It was dissolved in water and small quantity of insoluble
product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6-
trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-
trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide
dihydrochloride (zorubicin) was obtained as red-orange crystalline powder;
[α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form
of different non-toxic salts such as benzoates, fumarates, maleates, tartrates
and so on. The best among these compounds proves to be daunorubicin
benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No.
1,578,722 published in 1967, Class CO7d).
Therapeutic Function
Antineoplastic, Antileukemic
Check Digit Verification of cas no
The CAS Registry Mumber 36508-71-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,5,0 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 36508-71:
(7*3)+(6*6)+(5*5)+(4*0)+(3*8)+(2*7)+(1*1)=121
121 % 10 = 1
So 36508-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C34H35N3O10/c1-15-28(38)20(35)12-23(46-15)47-22-14-34(44,16(2)36-37-33(43)17-8-5-4-6-9-17)13-19-25(22)32(42)27-26(30(19)40)29(39)18-10-7-11-21(45-3)24(18)31(27)41/h4-11,15,20,22-23,28,38,40,42,44H,12-14,35H2,1-3H3,(H,37,43)/b36-16+
