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8-Quinolinecarbaldehyde thiosemicarbazone is a chemical compound with the molecular formula C13H11N3S. It is derived from the condensation of 8-quinolinecarbaldehyde with thiosemicarbazide, resulting in a thiosemicarbazone derivative. 8-Quinolinecarbaldehyde thiosemicarbazone is known for its potential applications in coordination chemistry, particularly as a ligand for the formation of metal complexes. It has been studied for its ability to bind with various metal ions, which can lead to the development of new materials with unique properties. The compound is also of interest in the field of medicinal chemistry due to its potential biological activities, such as antimicrobial and anticancer properties, although further research is needed to fully understand its therapeutic potential.

3652-39-9

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3652-39-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3652-39-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,5 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3652-39:
(6*3)+(5*6)+(4*5)+(3*2)+(2*3)+(1*9)=89
89 % 10 = 9
So 3652-39-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N4S/c12-11(16)15-14-7-9-4-1-3-8-5-2-6-13-10(8)9/h1-7H,(H3,12,15,16)/b14-7+

3652-39-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-quinolinecarboxaldehyde thiosemicarbazone

1.2 Other means of identification

Product number -
Other names 8-quinoline aldehyde thiosemicarbazone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3652-39-9 SDS

3652-39-9Downstream Products

3652-39-9Relevant academic research and scientific papers

Quinoline derivatives as potential anti-tubercular agents: Synthesis, molecular docking and mechanism of action

Liu, Chun-Xiu,Wang, Lei,Yang, Zai-Chang,Zhao, Xin

, (2022/04/03)

Development of new drugs with novel mechanisms of action is required to combat the problem of drug-resistant Mycobacterium tuberculosis. The present investigation is aimed at combining two pharmacophores (quinoline or isoquinolines and thiosemicarbazide) to synthesize a series of compounds. Seven compounds were synthesized based on combination principle in this study. The compound 1–7 showed activities against M. tuberculosis H37Rv strain with MIC values rang from 2 to 8 μg/ml. Compound 5 exhibited remarkable antimycobacterial activity (MIC = 2 μg/ml), and was therefore selected for study of the mechanism of action. Molecular docking suggested initially that compound 5 could occupy the active site of KatG of M. tuberculosis. Furthermore compound 5 exhibited potent inhibitory effect on activity of KatG. RT-PCR finally displayed that compound 5 could up-regulate the transcription of katG of M. tuberculosis. Together, these studies reveal that compound 5 might be the inhibitor of KatG of Mycobacterium tuberculosis. One of the more significant findings to emerge from this study is that KatG of M.tuberculosis can be used as a putative novel target for new anti-tubercular drug design.

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