365223-99-0Relevant academic research and scientific papers
Synthesis of benzocycloheptene-based amino acid derivatives via a [4+2] cycloaddition reaction as a key step
Kotha, Sambasivarao,Sreenivasachary, Nampally,Brahmachary, Enugurthi
, p. 6261 - 6265 (2001)
The seven-membered diene 5 is prepared from 2-butyne-1,4-diol using double orthoester Claisen rearrangement reaction as a key step. The Diels-Alder reaction of the diene 5 with various dienophiles followed by oxidation delivered the benzocycloheptene-based α-amino acid derivatives in very good yields.
