3654-22-6Relevant academic research and scientific papers
Catalytic system for inhibition of amination-type reaction and palladium-catalysed direct arylation using non-protected pyrazole derivatives
Derridj, Fazia,Roger, Julien,Djebbar, Safia,Doucet, Henri
experimental part, p. 747 - 750 (2012/04/23)
The palladium-catalysed direct arylation at C-4 of non-protected 5-aminopyrazoles was found to proceed in high yields using a variety of aryl bromides. The choice of potassium acetate as the base was found to be crucial to inhibit the amination reaction a
5-Aminopyrazoles from enolisable ketones and 1-cyano-1-alkylhydrazines
Ryckmans, Thomas,Viehe, Heinz-Gunter,Feneau-Dupont, Janine,Tinant, Bernard,Declercq, Jean-Paul
, p. 1729 - 1734 (2007/10/03)
The reaction of enolisable ketones with 1-alkyl-1-cyanohydrazines leads to the corresponding cyanohydrazones. These compounds cyclise under thermal or mildly basic conditions, furnishing the corresponding 5-aminopyrazoles in good yield. In some cases, the hydrazones cannot be isolated, and the pyrazole derivatives are directly obtained. Hydrazone-enehydrazine tautomerism was observed, but no subsequent [3,3] rearrangement.
