365427-24-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-Methoxyphenyl)-2-Methyl-1,3-thiazole is used as an intermediate in the synthesis of various pharmaceuticals for its potential anticancer and antifungal properties.
Used in Agrochemical Industry:
4-(3-Methoxyphenyl)-2-Methyl-1,3-thiazole is used as an insecticide and pesticide for its insecticidal and pesticidal activity, contributing to the development of agricultural products.

Upstream product

• 62-55-5 thioacetamide 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 122806-25-1 1-(3-methoxy-phenyl)-ethanone oxime 
• 108-24-7 acetic anhydride 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 

Downstream Products

• 239448-53-4 4-(3-methoxyphenyl)-2-methyl-5-phenylthiazole 

Relevant academic research and scientific papers

Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N-O/C-S bond cleavages, activation of vinyl sp2 C-H bond, and C-S/C-N bond formations which are under redox-neutral conditions as well as operational simplicity.

BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM

The present invention relates to benzofuran and benzothiophene derivatives and compositions containing such compounds for the production of medicaments for the treatment of cancers of the central nervous system as monotherapy or combination with other agents.

Aryl and heteroaryl sulfonates

The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating pain and neurodegen

BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.

An efficient synthesis of phenanthro-fused thiazoles by a non-phenolic oxidative coupling procedure of 4,5-diarylthiazoles

A concise synthesis of the title compounds 6 is accomplished in high overall yield in a two step process starting from bromoketone 4. A thiazole ring formation and a non-phenolic oxidative coupling reaction using PIFA are features of the described synthesis. An exploration of the electronic requirements and the regioselectivity of the cyclization is also presented.