365430-75-7Relevant academic research and scientific papers
Synthesis and biological activity of retinoic acid receptor-α specific amides
Beard, Richard L.,Duong, Tien T.,Teng, Min,Klein, Elliott S.,Standevan, Andrew M.,Chandraratna, Roshantha A.S.
, p. 3145 - 3148 (2007/10/03)
Retinoids are analogues of all-trans-retinoic acid, a powerful hormone that mediates many fundamental biological processes. Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids, but the therapeutic use of retinoids is limited due to severe toxicity. We report here the design of retinoid receptor-α specific ligands with growth inhibitory activity in breast cancer cell lines, and which do not cause the cutaneous toxicity associated with the currently available nonselective retinoid agonists.
Treatment of tumors with RARα selective retinoid compounds in combination with other anti-tumor agents
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, (2008/06/13)
Compounds which are specific or selective agonists of RARα receptors in preference over RARβ and RARγ receptors, and particularly compounds of the formula where R is a H, lower alkyl of 1 to 6 carbons, or a pharmaceutically acceptable salt, are useful for
Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents
-
, (2008/06/13)
Compounds which are specific or selective agonists of RARα receptors in preference over RARβ and RARγ receptors, and particularly compounds of the formula where R is a H, lower alkyl of 1 to 6 carbons, or a pharmaceutically acceptable salt, are useful for
