365565-88-4Relevant articles and documents
Discovery of novel N-(5-(tert-butyl)isoxazol-3-yl)-N′-phenylurea analogs as potent FLT3 inhibitors and evaluation of their activity against acute myeloid leukemia in vitro and in vivo
Xu, Ying,Wang, Ning-Yu,Song, Xue-Jiao,Lei, Qian,Ye, Ting-Hong,You, Xin-Yu,Zuo, Wei-Qiong,Xia, Yong,Zhang, Li-Dan,Yu, Luo-Ting
, p. 4333 - 4343 (2015/08/03)
FLT3 inhibitors have been explored as a viable therapy for acute myeloid leukemia (AML). However, the clinical outcomes of these FLT3 inhibitors were underwhelming except AC220. Therefore, the development of novel FLT3 inhibitors with high potency against