365569-51-3Relevant academic research and scientific papers
Verticilide: Elucidation of absolute configuration and total synthesis
Monma, Souichi,Sunazuka, Toshiaki,Nagai, Kenichiro,Arai, Takahiro,Shiomi, Kazuro,Matsui, Ryosuke,Omura, Satoshi
, p. 5601 - 5604 (2006)
Verticilide (1) is a 24-membered cyclic depsipeptide isolated from the culture broth of Verticillium sp. FKI-1033. It inhibits ryanodine binding to ryanodine receptor (RyR) and has insecticidal activity. The stereochemistry of 2-hydroxyheptanoic acid in v
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1
Kallander, Lara S.,Washburn, David,Hilfiker, Mark A.,Eidam, Hilary Schenck,Lawhorn, Brian G.,Prendergast, Joanne,Fox, Ryan,Dowdell, Sarah,Manns, Sharada,Hoang, Tram,Zhao, Steve,Ye, Guosen,Hammond, Marlys,Holt, Dennis A.,Roethke, Theresa,Hong, Xuan,Reid, Robert A.,Gampe, Robert,Zhang, Hong,Diaz, Elsie,Rendina, Alan R.,Quinn, Amy M.,Willette, Bob
supporting information, p. 736 - 740 (2018/07/25)
Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxamate BMP1 inhibitors was
HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
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Page/Page column 82, (2017/01/26)
Disclosed are compounds having the formula: (I) wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
N-HYDROXYFORMAMIDE COMPOUNDS AND COMPOSITIONS COMPRISING THEM FOR USE AS BMP1, TLL1 AND/OR TLL2 INHIBITORS
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Page/Page column 101-102, (2017/01/26)
Compounds of Formulas (I) and (II) and salts thereof; methods of making and using the same, including use for inhibiting BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
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Paragraph 0406; 0407, (2016/12/16)
Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
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Page/Page column 77, (2015/07/23)
Disclosed are compounds having the formula (I): wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.
