365572-48-1

Usage

Uses

Used in Pharmaceutical Industry:
C-(N-tert-butoxycarbonylamino)methanol is used as a synthetic reagent for the preparation of various pharmaceutical compounds. Its primary application is in the synthesis of somatotropin polypeptides, which act as antagonists to prevent the activation of growth hormone receptors. This makes it a valuable compound in the development of drugs targeting growth-related disorders and conditions.
Used in Chemical Synthesis:
In the chemical synthesis industry, C-(N-tert-butoxycarbonylamino)methanol serves as a versatile building block for the creation of a wide range of organic compounds. Its Boc-protected amino group allows for selective reactions, making it an essential component in the synthesis of complex molecules, such as pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Peptide Synthesis:
C-(N-tert-butoxycarbonylamino)methanol is also utilized in the field of peptide synthesis, where it is employed as a protecting group for amino groups during the assembly of peptide chains. The Boc group can be selectively removed when needed, allowing for the controlled stepwise synthesis of peptides and the introduction of specific amino acid residues at desired positions within the peptide sequence.

Upstream product

• 50-00-0 formaldehyd 
• 4248-19-5 tert-butyl carbazate 

Relevant academic research and scientific papers

Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction

The limited treatment options against influenza virus along with the growing public health concerns regarding the continuous emergence of drug-resistant viruses make essential the development of new anti-flu agents with novel mechanisms of action. One of

Palladium-Catalyzed Carboamination of Allylic Alcohols Using a Trifluoroacetaldehyde-Derived Tether

The selective palladium-catalyzed carboamination of allylic alcohols is reported on the basis of the use of an easily introduced trifluoroacetaldehyde-derived tether. Aminoalkynylation reactions were realized using alkynyl bromides and commercially available phosphine ligands. For aminoarylations, a new biaryl phosphine ligand, "Fu-XPhos", was introduced to overcome a competitive Heck pathway. The carboamination products were obtained in high yields and diastereoselectivity. The tether could be easily removed to give value-added amino alcohol building blocks.

Enantioselective organocatalytic intramolecular aza-Michael reaction: A concise synthesis of (+)-sedamine, (+)-allosedamine, and (+)-coniine

(Chemical Equation Presented) The intramolecular aza-Michael reaction of carbamates bearing remote α,β-unsaturated aldehydes under organocatalytic conditions took place with good yields and excellent ee's when Jorgensen catalyst IV was used in the process, giving rise to the enantioselective formation of several five- and six-membered heterocycles. The developed methodology was applied to the synthesis of three piperidine alkaloids.