36574-85-3Relevant academic research and scientific papers
Fast and efficient synthesis of flavanones from cinnamic acids
Bedane, Kibrom Gebreheiwot,Majinda, Runner R. T.,Masesane, Ishmael B.
, p. 1803 - 1809 (2016/11/18)
A fast and efficient synthesis of flavanones from cinnamic acids in three steps has been developed. First, the cinnamic acid was converted to cinnamyol chlorides using SOCl2. The acid chlorides were then treated with substituted phenols in BF3· OEt2to furnish corresponding chalcones in 42(75% yields. Base-catalyzed cyclization of the chalcones at room temperature afforded corresponding flavones in 85–95% yields. The conversion of the cinnamic acid derivatives to corresponding chalcones was found to be sensitive to the position and nature of the substituents on the aromatic rings.
Calcium hydroxide is an efficient catalyst for synthesis of polyhydroxy chalcones
Kulkarni,Swami,Zubaidha
, p. 617 - 620 (2013/07/19)
Calcium hydroxide was found to be an efficient catalyst for synthesis of polyhydroxy chalcones. This method has been employed to synthesize various 2′,4′-dihydroxychalcones having various substituents on the B ring. The merits of this method include shorter reaction time, inexpensive and easily available catalyst, high yield, and easy workup compared to other reported methods. Copyright Taylor and Francis Group, LLC.
Synthesis and evaluation of antiinflammatory activity of substituted chalcone derivatives
Zhang, Xue-Wu,Zhao, Dong-Hai,Quan, Ying-Chun,Sun, Liang-Peng,Yin, Xiu-Mei,Guan, Li-Ping
experimental part, p. 403 - 412 (2011/02/27)
In an effort to develop potent antiinflammatory agents, a series of substituted chalcone derivatives was synthesized and evaluated for antiinflammatory activity through monitoring of their ability to inhibit xylene-induced ear edema in mice. Some of the tested compounds exhibited significant activity, and compounds 3f [(E)-1-(2,4-dihydroxyphenyl)-3-(4- dimethylamino)phenyl)prop-2-en-1-one] and 3h [(E)-3-(4-chlorophenyl)-1-(2,4- dihydroxyphenyl)prop-2-en-1-one] showed the highest antiinflammatory activity (62 and 68% inhibition, respectively, 2 h before administration), comparable with or even slightly more potent than the reference drug ibuprofen (53%). Furthermore, the structure-activity relationship of these substituted chalcone derivatives was demonstrated.
