36596-61-9Relevant academic research and scientific papers
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain
Pinacho Crisostomo, Fernando R.,Feng, Yongmei,Zhu, Xuejun,Welsh, Kate,An, Jing,Reed, John C.,Huang, Ziwei
, p. 6413 - 6418 (2009)
Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represe
