36596-75-5Relevant academic research and scientific papers
Use of 2-Oxazolidinones As Latent Aziridine Equivalents. III. Preparation of N-Substituted Piperazines.
Poindexter, Graham S.,Bruce, Marc A.,LeBoulluec, Karen L.,Monkovic, Ivo
, p. 7331 - 7334 (2007/10/02)
A number of N-aryl and N-alkyl substituted piperazines 1 were prepared from variously substituted 2-oxazolidinone derivatives 3.The method involved treatment of 3 with HBr in glacial acetic acid followed by heating the resulting ring-opened salts 5 in alcoholic solvent.The piperazines 1a-1q were isolated by crystallization in yields ranging from 23-91percent.
Certain 2-substituted 1,3-propylidenediphosphonate derivatives, pharmaceutical compositions containing them and their use as antihypertensive agents
-
, (2008/06/13)
2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R1 and R2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases. They can be prepared by reacting phosphonating agents with 1,3- dibromopropanes or ditosylates of 1,3-propanediols substituted in position 2. STR1 .
