365996-86-7

Basic information

• Product Name: tert-butyl 2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
• Synonyms: tert-butyl 2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate ;2-Methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyriMidine-6-carboxylic acid tert-butyl ester;5,7-Dihydro-2-(methylthio)-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester;6-Boc-2-(methylthio)-5,7-dihydropyrrolo[3,4-d]pyrimidine;tert-Butyl 2-(methylthio)
• CAS NO: 365996-86-7
• Molecular Formula: C12H17N3O2S
• Molecular Weight: 267.351
• Mol File: 365996-86-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 402.9°C at 760 mmHg
• Flash Point: 197.4°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 1.06E-06mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: tert-butyl 2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate(365996-86-7)
• EPA Substance Registry System: tert-butyl 2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate(365996-86-7)

Safety Data

• Hazardous Substances Data: 365996-86-7(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate is a complex chemical compound consisting of a tert-butyl group, a methylthio group, and a pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate moiety. It is commonly used as a building block in the synthesis of various pharmaceuticals and specialty chemicals. tert-butyl 2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate is known to possess unique structural and functional properties, making it of interest to medicinal chemists and researchers in the field of drug discovery. It is important to handle this chemical with caution due to its potential reactivity and toxicity.

InChI:InChI=1/C12H17N3O2S/c1-12(2,3)17-11(16)15-6-8-5-13-10(18-4)14-9(8)7-15/h5H,6-7H2,1-4H3

Upstream product

• 14527-26-5 2-methylisothiourea sulphate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 905274-02-4 tert-butyl (3Z)-3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate 
• 857477-22-6 methylisothiourea monosulfate 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 157327-42-9 3-(dimethylaminomethylene)-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 867-44-7 S-Methylisothiourea sulfate 

Downstream Products

• 1454656-55-3 4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide 
• 1454656-81-5 4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide 
• 1454656-85-9 4-(2-(methylsulfinyl)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-N-(3-(trifluoromethyl)phenyl)picolinamide 
• 1454657-77-2 4-(2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-N-(3-(trifluoromethyl)phenyl)picolinamide 
• 947305-16-0 6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carbonitrile 
• 365996-87-8 tert-Butyl 2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate 

Relevant articles and documents

FUSED PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROTIC DISEASES

The present invention discloses compounds according to Formula I: Wherein A, B, R1, R2, and Cy are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, pain, and/or abnormal angiogenesis associated diseases by administering the compounds of the invention.

KINASE INHIBITORS

The present invention relates to compounds of formulae I and II wherein the variables are as defined herein. These compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (""DPP-IV inhibitors"") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.