365997-31-5

Basic information

• Product Name: ethyl (1R,4S,6S)-7-oxabicyclo[4.1.0]heptane-4-carboxylate
• Synonyms: ethyl (1R,4S,6S)-7-oxabicyclo[4.1.0]heptane-4-carboxylate;(1S,3S,6R)-7-Oxabicyclo[4.1.0]heptane-3-carboxylic acid ethyl ester
• CAS NO: 365997-31-5
• Molecular Formula: C₉H₁₄O₃
• Molecular Weight: 170.21
• Mol File: 365997-31-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl (1R,4S,6S)-7-oxabicyclo[4.1.0]heptane-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (1R,4S,6S)-7-oxabicyclo[4.1.0]heptane-4-carboxylate(365997-31-5)
• EPA Substance Registry System: ethyl (1R,4S,6S)-7-oxabicyclo[4.1.0]heptane-4-carboxylate(365997-31-5)

Safety Data

• Hazardous Substances Data: 365997-31-5(Hazardous Substances Data)

Usage

General Description

Ethyl (1R,4S,6S)-7-oxabicyclo[4.1.0]heptane-4-carboxylate is a chemical compound with a complex and specific structure. It is classified as an ester, as indicated by the presence of the ethyl group and the carboxylate functional group. The compound is a bicyclic organic molecule with a seven-membered ring structure, containing oxygen and carbon atoms in its framework. The stereochemistry of the molecule is specified by the (1R,4S,6S) designation, indicating the configuration of its chiral centers. ethyl (1R,4S,6S)-7-oxabicyclo[4.1.0]heptane-4-carboxylate may have potential applications in pharmaceuticals, agrochemicals, or materials synthesis, owing to its unique structure and properties. Further research and analysis are likely necessary to fully understand and harness the potential of this chemical compound.

Upstream product

• 64-17-5 ethanol 
• 139893-81-5 (1S,4S,5S)-4-bromo-6-oxabicyclo<3.2.1>octan-7-one 
• 5708-19-0 (1S)-3-cyclohexenecarboxylic acid 
• 4771-80-6 1,2,5,6-tetrahydrobenzoic acid 
• 67976-82-3 (1S)-3-cyclohexene-1-carboxylic acid (R)-(+)-α-methylbenzylamine salt 
• 123536-66-3 (1S,4S,5S)-4-iodo-6-oxabicyclo<3.2.1>octan-7-one 

Downstream Products

• 365997-32-6 ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate 
• 365997-36-0 (1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester 
• 1255529-35-1 ethyl (1S,3R,4R)-4-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 
• 365997-34-8 ethyl (1S,3R,4S)-4-azido-3-(tert-butoxycarbonylamino)-cyclohexane-1-carboxylate 
• 365998-33-0 ethyl (1S,3R,4S)-4-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate 
• 1255529-37-3 (1R,2R,4R)-2-[(Tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester 
• 1255529-53-3 (1S,2R,4R)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexylcarbamic acid benzyl ester 
• 929693-34-5 ethyl (1S,3R,4R)-3-amino-4-hydroxycyclohexanecarboxylate 
• 480449-84-1 ethyl (1S,3R,4S)-4-amino-3-[(tert-butoxycarbonyl)amino]-cyclohexanecarboxylate 
• 1255529-36-2 ethyl (1R,3R,4R)-4-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 
• 480450-69-9 tert-butyl N-[(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate 

Relevant articles and documents

Preparation method of edoxaban tosylate and isomers thereof

The invention discloses a preparation method of edoxaban tosylate and isomers thereof. By taking a compound (I) and a compound (II) as starting materials, the method can be used to prepare any one ofhigh-purity edoxaban tosylate (1S, 2R, 4S), edoxaban tosylate enantiomers (1R, 2S, 4R), edoxaban tosylate epimers (1R, 2R, 4S) and edoxaban tosylate epimers (1S, 2S, 4R). Effective guarantee is provided for process research and quality control of the edoxaban tosylate bulk drug and related preparations, the preparation method is suitable for commercialization, the produced edoxaban tosylate bulk drug is high in purity and has great significance and practical value, and the production of the edoxaban tosylate bulk drug and the control of drug quality are facilitated.

SALT OF AMINE-PROTECTED (1S,2R,4S)-1,2-AMINO-N,N-DIMETHYLCYCLOHEXANE-4-CARBOXAMIDE

Disclosed are compounds and methods for the preparation of Edoxaban. In particular, a camphor sulfonate salt of an amine-protected [(1R,2S,5S)-1,2-amino-5-[(dimethylamino)carbonyl] cyclohexane, an intermediate that may be formed in the synthesis of Edoxaban, is disclosed as well as methods of its preparation.

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa

In the early 1990's, we reported on the low-molecular selective fXa inhibitor DX-9065a having two amidino groups. However, it had poor oral bioavailability due to its strong basic amidino groups. To obtain fXa inhibitors with improved oral bioavailability