36635-71-9Relevant academic research and scientific papers
Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
Park, Cheon-Soo,Ahn, Yongchel,Lee, Dahae,Moon, Sung Won,Kim, Ki Hyun,Yamabe, Noriko,Hwang, Gwi Seo,Jang, Hyuk Jai,Lee, Heesu,Kang, Ki Sung,Lee, Jae Wook
, p. 5705 - 5707 (2015)
Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in contro
1-Arylvinyl formats: A New CO Source and Ketone Source in Carbonylative Synthesis of Chalcone Derivatives
Qi, Xinxin,Lai, Ming,Zhu, Min-Jie,Peng, Jin-Bao,Ying, Jun,Wu, Xiao-Feng
, p. 5252 - 5255 (2019/02/25)
1-Arylvinyl formates as a kind of new CO surrogate have been explored for the first time. Most of the known CO precursors usually produce undesired residuals, which have to be removed. In this strategy, after CO release, the in situ generated acetophenones from 1-arylvinyl formates can be successfully applied as a good ketone source in the synthesis of chalcones with benzaldehydes via a palladium-catalyzed reductive carbonylation reaction. A variety of chalcones were isolated in satisfactory to good yields with good substrates compatibilities under mild conditions.
