36646-79-4

Upstream product

• 493-72-1 5-phenyl-cyclohexane-1,3-dione 
• 62-53-3 aniline 
• 35376-44-4 3-hydroxy-5-phenylcyclohex-2-en-1-one 

Downstream Products

• 1158819-92-1 C₂₇H₂₁NO₄ 
• 1423126-34-4 2,4-diphenylpyrrolo[2,3,4-kl]acridin-1(2H)-one 
• 1423126-38-8 9-fluoro-2,4-diphenylpyrrolo[2,3,4-kl]acridin-1(2H)-one 
• 1154040-36-4 3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,6-diphenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione 

Relevant academic research and scientific papers

Cyclization of cyanoethylated ketones as a route to 6-substituted indole derivatives

δ-Cyanoketones are quickly cyclized with KOtBu to 3-aminocyclohex-2-enone derivatives, which in turn will give substituted indoles when treated with oxalyl chloride. Thus, 3-amino-6,6-dimethylcyclohex-2-enone gave 3-chloro-6,6-dimethyl-2,5,6,7-tetrahydroindole-2,5-dione, whose structure was corroborated by X-ray crystallography, whereas the corresponding molecule without the blocking gem-dimethyl groups, 3-aminocyclohex-2-enone, gave via hydrogen shifts 6-chloro-3-hydroxyoxindole.

Synthesis of enaminones in aqueous media using catalytic dilute HCl

(Chemical Equation Presented) A green and convenient approach to the synthesis of β-enaminones from aromatic amines and 5-substituted-1,3- cyclohexanedione in the presence of dilute hydrochloric acid (30 mmol=L) as a catalyst in solvent-free media is described. This method provides several advantages such as environmental friendliness, low cost, good yields, and simple workup procedure. Copyright Taylor & Francis Group, LLC.

Partially saturated indeno[1,2-b]indole derivatives via deoxygenation of heterocyclic α-hydroxy-N,O-hemiaminals

A series of 3-aminocyclohex-2-enones were reacted with indane-1,2,3-trione monohydrate (ninhydrin) yielding 4b,9b-dihydroxyindeno[ 1,2-b]indoles that were deoxygenated to indeno[1,2-b]indoles. Georg Thieme Verlag Stuttgart.