366475-96-9

Upstream product

• 366469-92-3 (R)-4-Benzoyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 366469-80-9 (R)-4-(Hydroxy-phenyl-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 133464-37-6 (4R)-4-formyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester 
• 93204-36-5 (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxypropanoate 
• 133464-35-4 3-benzyl 4-methyl (4R)-2,2-dimethyloxazolidine-3,4-dicarboxylate 
• 501-53-1 benzyl chloroformate 

Relevant academic research and scientific papers

The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd.