366487-74-3 Usage
Uses
Used in Pharmaceutical Synthesis:
N-BOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHE& is used as a chiral building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the creation of enantiomerically pure compounds, which are essential in the development of effective and safe medications.
Used in Medicinal Chemistry:
N-BOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHE& is used as a starting material for the synthesis of bioactive molecules in medicinal chemistry. The presence of the BOC protecting group and the nitrophenyl group allows for the development of novel compounds with potential therapeutic applications.
Used in Drug Development:
N-BOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHE& is used as a key intermediate in the development of new drugs. Its chiral nature and functional groups make it a valuable component in the design and synthesis of innovative pharmaceuticals with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 366487-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,6,4,8 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 366487-74:
(8*3)+(7*6)+(6*6)+(5*4)+(4*8)+(3*7)+(2*7)+(1*4)=193
193 % 10 = 3
So 366487-74-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H20N2O6/c1-14(2,3)22-13(19)15-11(8-17)12(18)9-4-6-10(7-5-9)16(20)21/h4-7,11-12,17-18H,8H2,1-3H3,(H,15,19)/t11-,12-/m1/s1
366487-74-3Relevant academic research and scientific papers
Experimental and DEE study of the conversion of ephedrine derivatives into oxazolidinones. Double SN2 mechanism against SN1 mechanism
El Moncef, Abdelkarim,El Hadrami, El Mestafa,González, Miguel A.,Zaballos, Elena,Zaragozá, Ramón J.
experimental part, p. 5173 - 5184 (2010/08/22)
Sulfonation of the N-Boc derivatives of 1,2-aminoalcohols, such as ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine, thiomicamine, and chloramphenicol yields a mixture of the corresponding oxazolidinones with inversion (erythro derivatives) and!or retention of configuration (threo derivatives)at C5. We suggest a competition between two mechanisms: an intramolecular SN2 process initiated by attack of the carbonyl oxygen of the Boc group to the benzylic carbon and the other one through a double SN2 process. In the erythro derivatives the first mechanism is predominant, while in the threo derivatives both mechanisms have similar energy. This hypothesis is supported by theoretical calculations and additional experimental assays.
