366783-29-1Relevant articles and documents
A lysosome-targeted near-infrared photosensitizer for photodynamic therapy and two-photon fluorescence imaging
Tu, Yinuo,Wang, Lei,Wu, Xu,Xia, Weikang
, p. 6098 - 6107 (2021/07/21)
Organelle-targeted two-photon near-infrared photosensitizers are highly desirable for photodynamic therapy (PDT) of cancer. Herein, in this contribution, we have developed a 2-dicyanomethylenethiazole-based D-π-A structured near-infrared photosensitizer (TTR).TTRexhibits near-infrared emission (704 nm), a large Stokes shift (200 nm), and smaller ΔES1-T1(the energy gap between S1and T1) (0.717 eV).In vitroresults show thatTTRcan specifically target lysosomes in living cells for near-infrared fluorescence imaging. With efficient ROS generation, excellent biocompatibility, two-photon imaging capability, and depth imaging (21 μmin vitroand 210 μmin vivo),TTRcan effectively kill tumor cells and inhibit the growth of subcutaneous tumors. The hematoxylin-eosin (H&E) staining and blood biochemical parameter results further prove the biocompatibility ofTTR. Hence,TTRcan be a promising photosensitizer for PDT.