366783-29-1

Basic information

• Product Name: Propanedinitrile, 2(3H)-thiazolylidene- (9CI)
• Synonyms: Propanedinitrile, 2(3H)-thiazolylidene- (9CI)
• CAS NO: 366783-29-1
• Molecular Formula: C6H3N3S
• Molecular Weight: 149.17
• Mol File: 366783-29-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanedinitrile, 2(3H)-thiazolylidene- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, 2(3H)-thiazolylidene- (9CI)(366783-29-1)
• EPA Substance Registry System: Propanedinitrile, 2(3H)-thiazolylidene- (9CI)(366783-29-1)

Safety Data

• Hazardous Substances Data: 366783-29-1(Hazardous Substances Data)

Upstream product

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Relevant articles and documents

A lysosome-targeted near-infrared photosensitizer for photodynamic therapy and two-photon fluorescence imaging

Organelle-targeted two-photon near-infrared photosensitizers are highly desirable for photodynamic therapy (PDT) of cancer. Herein, in this contribution, we have developed a 2-dicyanomethylenethiazole-based D-π-A structured near-infrared photosensitizer (TTR).TTRexhibits near-infrared emission (704 nm), a large Stokes shift (200 nm), and smaller ΔES1-T1(the energy gap between S1and T1) (0.717 eV).In vitroresults show thatTTRcan specifically target lysosomes in living cells for near-infrared fluorescence imaging. With efficient ROS generation, excellent biocompatibility, two-photon imaging capability, and depth imaging (21 μmin vitroand 210 μmin vivo),TTRcan effectively kill tumor cells and inhibit the growth of subcutaneous tumors. The hematoxylin-eosin (H&E) staining and blood biochemical parameter results further prove the biocompatibility ofTTR. Hence,TTRcan be a promising photosensitizer for PDT.