3671-60-1 Usage
Uses
Used in Medicinal Chemistry:
1H-BENZIMIDAZOLE, 6-BROMO-2-(TRIFLUOROMETHYL)is used as a building block for the synthesis of various functionalized benzimidazole derivatives due to its structural features and potential biological activities.
Used in Pharmaceutical Chemistry:
1H-BENZIMIDAZOLE, 6-BROMO-2-(TRIFLUOROMETHYL)is used as a starting material for the development of new drug molecules, particularly in the design of compounds with improved pharmacokinetic properties. The trifluoromethyl group and bromine atom contribute to the compound's versatility and potential for use in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 3671-60-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,7 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3671-60:
(6*3)+(5*6)+(4*7)+(3*1)+(2*6)+(1*0)=91
91 % 10 = 1
So 3671-60-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H4BrF3N2/c9-4-1-2-5-6(3-4)14-7(13-5)8(10,11)12/h1-3H,(H,13,14)
3671-60-1Relevant academic research and scientific papers
Fe(OTf)3-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles from o-arylenediamines and hexafluoroacetylacetone
Zhou, Yanmei,Shen, Guanshuo,Sui, Yuebo,Zhou, Haifeng
supporting information, p. 3396 - 3399 (2016/07/11)
An iron-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles through condensation of o-arylenediamines and hexafluoroacetylacetone followed by intramolecular addition and C–C bond cleavage in one-pot has been developed. A series of title compounds were obtained with up to 99% yield. This method is quite practical and suitable for scalable preparation due to simple experimental procedure and readily available reagents.
