36717-14-3

Basic information

• Product Name: N-{[3-(trifluoromethyl)phenyl]carbamothioyl}acetamide
• Synonyms: N-{[3-(trifluoromethyl)phenyl]carbamothioyl}acetamide
• CAS NO: 36717-14-3
• Molecular Weight: 262.255
• Mol File: 36717-14-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{[3-(trifluoromethyl)phenyl]carbamothioyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{[3-(trifluoromethyl)phenyl]carbamothioyl}acetamide(36717-14-3)
• EPA Substance Registry System: N-{[3-(trifluoromethyl)phenyl]carbamothioyl}acetamide(36717-14-3)

Safety Data

• Hazardous Substances Data: 36717-14-3(Hazardous Substances Data)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 13250-46-9 acetyl isothiocyanate 

Relevant articles and documents

Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl)phenyl moiety

A total of 31 of thiourea derivatives was prepared reacting 3-(trifluoromethyl)aniline and commercial aliphatic and aromatic isothiocyanates. The yields varied from 35% to 82%. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 3, 5, 6, 9, 15, 24 and 27 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.25e16 μg/ml. Inhibitory activity of thioureas 5 and 15 against topoisomerase IV isolated from Staphylococcus aureus was studied. Products 5 and 15 effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of Staphylococcus epidermidis. Moreover, all obtained thioureas were evaluated for cytotoxicity and antiviral activity against a large panel of DNA and RNA viruses. Compounds 5, 6, 8e12, 15 resulted cytotoxic against MT-4 cells (CC50≤ 10μM).