36717-77-8

Basic information

• Product Name: 2-(2-nitro-1H-imidazol-1-yl)ethanamine
• CAS NO: 36717-77-8
• Molecular Formula: C₅H₈N₄O₂
• Molecular Weight: 156.1426
• Mol File: 36717-77-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 372°C at 760 mmHg
• Flash Point: 178.8°C
• Density: 1.52g/cm³
• Vapor Pressure: 9.94E-06mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 2-(2-nitro-1H-imidazol-1-yl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-nitro-1H-imidazol-1-yl)ethanamine(36717-77-8)
• EPA Substance Registry System: 2-(2-nitro-1H-imidazol-1-yl)ethanamine(36717-77-8)

Safety Data

• Hazardous Substances Data: 36717-77-8(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Contains

A nitro group and an imidazole ring

Known for

Diverse biological activities

Potential pharmacological uses

Infectious diseases and cancer treatment

Antimicrobial agent

Shown promise

Anti-tumor potential

Been investigated

Combination therapy

Explored for enhanced effectiveness with other drugs

Interest in pharmaceutical industry

Due to its interesting pharmacological properties

Upstream product

• 1300727-12-1 tert-butyl 2-(2-nitro-1H-imidazol-1-yl)ethylcarbamate 
• 4055-39-4 mitomycin A 
• 100579-78-0 N-[2-(2-nitro-1H-imidazolyl)ethyl]phthalimide 
• 81054-93-5 1-(2-chloroethyl)-2-nitroimidazole 
• 22903-73-7 2-(2-nitro-imidazol-1-yl)-acetamide 

Downstream Products

• 1443039-71-1 3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide 
• 1443039-74-4 3-(ditert-butylsilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide 
• 1422736-88-6 C₃₉H₄₇N₆O₂⁽¹⁺⁾*I^(1-) 
• 116989-51-6 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride 

Relevant articles and documents

Novel 99mTc labelled complexes with 2-nitroimidazole isocyanide: Design, synthesis and evaluation as potential tumor hypoxia imaging agents

Radiolabelled 2-nitroimidazoles have been used for imaging hypoxia. With the aim of developing novel 99mTc radiotracers for imaging hypoxia, four novel 2-nitroimidazole isocyanide derivatives (2a, 2b, 2c, and 2d) were synthesized and radiolabelling was carried out for preparing their corresponding 99mTc complexes. These 99mTc complexes were stable in vitro and could exhibit good hypoxic selectivity. The partition coefficient results indicated that they were hydrophilic, and an evaluation of biodistribution in mice bearing S180 tumors indicated that all of the complexes could accumulate in the tumors. Among them, 99mTc-2c exhibited the highest tumor uptake and tumor/blood and tumor/muscle ratios at 2 h post-injection. Further, single photon emission computed tomography (SPECT) imaging studies indicated clear accumulation in tumors, suggesting that 99mTc-2c was a promising candidate for hypoxia imaging.

Real time detection of ESKAPE pathogens by a nitroreductase-triggered fluorescence turn-on probe

The identification of bacterial pathogens is the critical first step in conquering infection diseases. A novel turn-on fluorescent probe for the selective sensing of nitroreductase (NTR) activity and its initial applications in rapid, real-time detection and identification of ESKAPE pathogens have been reported.

High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed and was successfully applied to investigating the relationship between epithelial-mesenchymal transitions (EMTs) in tumour progression and intracellular hypoxic level.