367258-63-7

Upstream product

• 367258-62-6 12-cyclohexyl-6,6,11,14-tetraoxo-2-oxa-6λ⁶-thia-10,13-diazatricyclo[14.3.1.1^7,10]henicosa-1(19),16(20),17-triene-9-carboxylic acid methyl ester 
• 367258-60-4 12-cyclohexyl-11,14-dioxo-2-oxa-6-thia-10,13-diazatricyclo[14.3.1.1^7,10]henicosa-1⁽¹⁹⁾,16⁽²⁰⁾,17-triene-9-carboxylic acid methyl ester 

Downstream Products

• 368871-17-4 (7R,9S,12S)-12-Cyclohexyl-6,6,11,14-tetraoxo-2-oxa-6λ⁶-thia-10,13-diaza-tricyclo[14.3.1.1^7,10]henicosa-1(20),16,18-triene-9-carboxylic acid {1-[({[((S)-dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-butyl}-amide 

Relevant academic research and scientific papers

Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles

The hepatitis C virus (HCV) NS3 protease is essential for viral replication. It has been a target of choice for intensive drug discovery research. On the basis of an active pentapeptide inhibitor, 1, we envisioned that macrocyclization from the P2 proline