367259-30-1Relevant academic research and scientific papers
P2-P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease
Arasappan, Ashok,Njoroge, F. George,Chen, Kevin X.,Venkatraman, Srikanth,Parekh, Tejal N.,Gu, Haining,Pichardo, John,Butkiewicz, Nancy,Prongay, Andrew,Madison, Vincent,Girijavallabhan, Viyyoor
, p. 3960 - 3965 (2007/10/03)
Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
