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367259-52-7

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367259-52-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 367259-52-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,7,2,5 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 367259-52:
(8*3)+(7*6)+(6*7)+(5*2)+(4*5)+(3*9)+(2*5)+(1*2)=177
177 % 10 = 7
So 367259-52-7 is a valid CAS Registry Number.

367259-52-7Downstream Products

367259-52-7Relevant articles and documents

Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease

Chen, Kevin X.,Njoroge, F. George,Pichardo, John,Prongay, Andrew,Butkiewicz, Nancy,Yao, Nanhua,Madison, Vincent,Girijavallabhan, Viyyoor

, p. 567 - 574 (2007/10/03)

The NS3 protease of hepatitis C virus (HCV) has emerged as one of the best characterized targets for next-generation HCV therapy. The tetrapeptide 1 and pentapeptide 2 are α-ketoamide-type HCV serine protease inhibitors with modest potency. We envisioned

Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease

Chen, Kevin X.,Njoroge, F. George,Pichardo, John,Prongay, Andrew,Butkiewicz, Nancy,Yao, Nanhua,Madison, Vincent,Girijavallabhan, Viyyoor

, p. 6229 - 6235 (2007/10/03)

The limited efficacy and considerable side effects of currently available therapies for the treatment of hepatitis C virus (HCV) infection have prompted significant efforts toward the development of safe and effective new therapeutics. The pentapeptide α-

Proline-based macrocyclic inhibitors of the hepatitis C virus: Stereoselective synthesis and biological activity

Chen, Kevin X.,Njoroge, F. George,Vibulbhan, Bancha,Prongay, Andrew,Pichardo, John,Madison, Vincent,Buevich, Alexei,Chan, Tze-Ming

, p. 7024 - 7028 (2007/10/03)

Life-saving donut: Macrocyclization through a Mitsunobu reaction was used to synthesize a 17-membered macrocycle. The bicyclic acetal core was prepared completely diastereoselectively. The macrocyclic peptidomimetic surrogate of the P2-P3 dipeptide moiety was designed to function as a hepatitis C virus (HCV) NS3 serine protease inhibitor, and the pentapeptide α-ketoamides derived from the macrocycle were shown to be potent HCV inhibitors. (Figure Presented).

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