367260-22-8

Upstream product

• 367261-52-7 (S)-Cyclohexyl-(4-nitro-phenoxycarbonylamino)-acetic acid ethyl ester 
• 33905-38-3 3-(benzyloxy)-N-methylaniline 
• 753387-55-2 ethyl (2S)-amino(cyclohexyl)acetate 

Downstream Products

• 906375-45-9 (2S,4R)-1-{(S)-2-[3-(3-Benzyloxy-phenyl)-3-methyl-ureido]-2-cyclohexyl-acetyl}-4-(3-benzyloxy-propoxy)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 906375-48-2 (5S,8S,10R)-5-Cyclohexyl-2-methyl-3,6-dioxo-11,15-dioxa-2,4,7-triaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽¹⁹⁾,16⁽²⁰⁾,17-triene-8-carboxylic acid tert-butyl ester 
• 906375-51-7 (5S,8S,10R)-5-Cyclohexyl-2-methyl-3,6-dioxo-11,15-dioxa-2,4,7-triaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽¹⁹⁾,16⁽²⁰⁾,17-triene-8-carboxylic acid 

Relevant academic research and scientific papers

P2-P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.