36727-44-3Relevant academic research and scientific papers
New strategy for production of primary alcohols from aliphatic olefins by tandem cross-metathesis/hydrogenation
Jia, Ruilong,Zuo, Zhijun,Li, Xu,Liu, Lei,Dong, Jinxiang
, p. 1525 - 1529 (2020)
Primary alcohols are widely used in industry as solvents and precursors of detergents. The classic methods for hydration of terminal alkenes always produce the Markovnikov products. Herein, we reported a reliable approach to produce primary alcohols from terminal alkenes combining with biomass-derived allyl alcohol by tandem cross-metathesis/hydrogenation. A series of primary alcohol with different chain lengths was successfully produced in high yields (ca. 90percent). Computational studies revealed that self-metathesis and hydrogenation of substrates are accessible but much slower than cross-metathesis. This new methodology represents a unique alternative to primary alcohols from terminal alkenes.
Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate
Sturgess, Dayna,Chen, Zongjia,White, Jonathan M.,Rizzacasa, Mark A.
, p. 234 - 239 (2018/03/21)
The total syntheses of both the natural and unnatural enantiomers of the alkyl citrate natural product CJ-13,982 (1) from the common d-ribose-derived acid 6 are described.
REGIOSPECIFIC RING OPENING OF α,β-EPOXYSILANES WITH SILICON TETRAFLUORIDE AND APPLICATION TO THE SYNTHESIS OF FLUOROALKENES
Shimizu, Makoto,Yoshioka, Hirosuke
, p. 967 - 970 (2007/10/02)
α,β-Epoxysilanes undergo the ring opening-fluorination with silicon tetrafluoride in the presence of diisopropylethylamine and water to give β-fluoro-β-silyl alcohols specifically, and the subsequent olefination with potassium hexamethyldisilazide affords fluoroalkenes in good yield.
