367274-56-4

Upstream product

• 15030-72-5 Z-Aib-OH 
• 367274-58-6 2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one 

Downstream Products

• 6671-25-6 2-(2-benzyloxycarbonylamino-2-methyl-propionylamino)-2-methylpropionic acid methyl ester 
• 132682-05-4 tert-butyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-prolinate 
• 3350-42-3 methyl N-(2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-alaninate 
• 84758-67-8 methyl N-(2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)glycinate 
• 663604-71-5 Z-(Aib)2-L-Leu-(Aib)2-NHPy 
• 663604-69-1 {1-methyl-1-[1-methyl-1-(pyridin-4-ylcarbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis

A new bio-inspired approach is reported for amide and peptide synthesis using α-amino esters that possess a potential activating group (PAG) at the ester residue. To activate the ester functionality under mild metal-free conditions, we exploited the facile dearomatization of phenols with hypervalent iodine(iii) reagents. Using a pyridine-hydrogen fluoride complex, highly reactive acyl fluoride intermediates can be successfully generated, thereby allowing for the smooth formation of sterically hindered amides and peptides from bulky amines and α-amino esters, respectively.