36740-73-5

Basic information

• Product Name: Flumizole
• Synonyms: Flumizole;4,5-Bis(4-methoxyphenyl)-2-(trifluoromethyl)-1H-imidazole;CP-22665
• CAS NO: 36740-73-5
• Molecular Formula: C18H15F3N2O2
• Molecular Weight: 348.3191
• Mol File: 36740-73-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 458.4°Cat760mmHg
• Flash Point: 231.1°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 3.74E-08mmHg at 25°C
• Refractive Index: 1.544
• PKA: pKa 10.7 (Uncertain)
• CAS DataBase Reference: Flumizole(CAS DataBase Reference)
• NIST Chemistry Reference: Flumizole(36740-73-5)
• EPA Substance Registry System: Flumizole(36740-73-5)

Safety Data

• Hazardous Substances Data: 36740-73-5(Hazardous Substances Data)

Usage

Uses

Anti-inflammatory.

InChI:InChI=1/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)

Relevant articles and documents

Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles

A number of trisubstituted imidazoles were made and several found to be potent antiinflammatory agents when examined in the carrageenan rat paw edema test. The antiinflammatory activity of these compounds is retained in adrenalectomized rats. Unlike many previously reported antiinflammatory agents, these compounds are extremely weak acids pK[a] ≥ 11) and are therefore not ionized at physiological pH. One compound, 4,5 bis (4 methoxyphenyl) 2 trifluoromethylimidazole (flumizole), is more potent than indometacin in the rat paw edema test and, in contrast to some related compounds, does not cause photosensitization in mice.