36748-99-9

Upstream product

• 13019-32-4 7-bromo-8-hydroxyquinoline 
• 74-88-4 methyl iodide 

Downstream Products

• 938-33-0 8-methoxyquinoline 
• 36749-00-5 7-iodo-8-methoxyquinoline 
• 172795-87-8 2,2-dimethyl-N-(2-(8-methoxy-7-quinolyl)phenyl)propanamide 
• 172795-96-9 2,2-dimethyl-N-(4-methoxy-2-(8-methoxy-7-quinolyl)phenyl)propanamide 
• 299926-53-7 1-(2,3-dimethoxyphenyl)-2-(8-methoxyquinolin-7-yl)ethane 
• 299926-55-9 1-(2,3-dihydroxyphenyl)-2-(8-hydroxyquinolin-7-yl)ethane 
• 172795-88-9 7-(2-aminophenyl)-8-methoxyquinoline 
• 172795-89-0 7-(2-azidophenyl)-8-methoxyquinoline 
• 172795-97-0 7-(2-amino-5-methoxyphenyl)-8-methoxyquinoline 
• 172795-98-1 7-(2-azido-5-methoxyphenyl)-8-methoxyquinoline 

Relevant academic research and scientific papers

FATTY ACID SYNTHASE INHIBITORS

This invention relates to novel spirocyclic piperidines according to Formula (I) which are inhibitors of fatty acid synthase (FAS), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

FATTY ACID SYNTHASE INHIBITORS

This invention relates to spirocyclic piperidines according to Formula (I) and the use of spirocyclic piperidines for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer.

FATTY ACID SYNTHASE INHIBITORS

Disclosed are compounds having Formula (I), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R8a, R9 Y, and m are defined herein and methods of using the same.

Synthesis of substituted 8-methoxyquinolines by regioselective bromine-lithium exchange of 5,7-dihalo-8-methoxyquinolines and 7-bromo-8-methoxyquinoline

Reaction of phenyllithium with 7-bromo-8-methoxyquinoline, 5,7-dibromo-8-methoxyquinoline and 5,7-diiodo-8-methoxyquinoline has been studied. Thus, bromine-lithium exchange of 7-bromo-8-methoxyquinoline gave the 7-lithio-8-methoxyquinoline which reacted with various electrophiles to afford 7-substituted 8-methoxyquinolines 3a-e. The same procedure was also applied to 5,7-dibromo-8-methoxyquinoline, which because of the high regioselectivity of the reaction, led to 7-substituted 5-bromo-8-methoxyquinolines 4a-f; one of them was used for the preparation of a pyridopyranoquinoline.