36749-59-4

Basic information

• Product Name: 2-(4-hydroxy-3,5-dimethylphenyl)-1H-indene-1,3(2H)-dione
• Synonyms: 2-(4-Hydroxy-3,5-dimethylphenyl)-1H-indene-1,3(2H)-dione
• CAS NO: 36749-59-4
• Molecular Formula: C₁₇H₁₄O₃
• Molecular Weight: 266.2913
• Mol File: 36749-59-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 474.7°C at 760 mmHg
• Flash Point: 255°C
• Density: 1.288g/cm³
• Vapor Pressure: 1.24E-09mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 2-(4-hydroxy-3,5-dimethylphenyl)-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-hydroxy-3,5-dimethylphenyl)-1H-indene-1,3(2H)-dione(36749-59-4)
• EPA Substance Registry System: 2-(4-hydroxy-3,5-dimethylphenyl)-1H-indene-1,3(2H)-dione(36749-59-4)

Safety Data

• Hazardous Substances Data: 36749-59-4(Hazardous Substances Data)

Usage

Origin

Synthetic derivative of podophyllotoxin

Usage

Chemotherapeutic agent

Commonly used for

Treatment of various types of cancer (e.g., lung cancer, testicular cancer, and lymphomas)

Mechanism of action

Inhibits the enzyme topoisomerase II, which is involved in DNA replication and repair

Effect on cells

Accumulation of DNA damage, leading to cell death and suppression of cancer cell growth

Administration

Typically administered intravenously or orally

Combination therapy

Often used with other chemotherapy drugs for maximum effectiveness

Side effects

Can cause serious side effects, such as myelosuppression and an increased risk of secondary leukemia

Supervision

Should be used under the guidance of a healthcare professional