367512-50-3Relevant academic research and scientific papers
A simple and convenient synthesis of β-amino alcohol chiral auxiliaries based on limonene oxide
Chrisman, Will,Camara, Jason N.,Marcellini, Kim,Singaram, Bakthan,Goralski, Christian T.,Hasha, Dennis L.,Rudolf, Philip R.,Nicholson, Lawrence W.,Borodychuk, Karen K.
, p. 5805 - 5807 (2001)
A series of chiral β-amino alcohols was prepared by the reaction of secondary amines with a 1:1 mixture of cis- and trans-limonene oxide in the presence of water as a catalyst. The β-amino alcohol obtained was derived from the trans-limonene oxide, and the unreacted cis-limonene oxide was recovered from the reaction mixture. The β-amino alcohols are useful chiral auxiliaries for the addition of diethylzinc to benzaldehyde.
Chiral amino alcohols and process for preparation of same
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Example 23, (2008/06/13)
The disclosed invention comprises a compound having the formula: in which R1and R2independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the disclosed chiral amino alcohols from a starting amine compound and a limonene oxide.
