367519-85-5Relevant articles and documents
Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors
Chirapu, Srinivas Reddy,Pachaiyappan, Boobalan,Nural, Hikmet F.,Cheng, Xin,Yuan, Hongbin,Lankin, David C.,Abdul-Hay, Samer O.,Thatcher, Gregory R.J.,Shen, Yong,Kozikowski, Alan P.,Petukhov, Pavel A.
body text, p. 264 - 274 (2009/05/26)
A series of transition state analogues of beta-secretases 1 and 2 (BACE1, 2) inhibitors containing fused-ring or biaryl moieties were designed computationally to probe the S2 pocket, synthesized, and tested for BACE1 and BACE2 inhibitory activity. It has
