367521-07-1

Basic information

• Product Name: 5-AMino-2,4-dibroMophenol
• Synonyms: 5-AMino-2,4-dibroMophenol
• CAS NO: 367521-07-1
• Molecular Formula: C₆H₅Br₂NO
• Molecular Weight: 266.918
• Mol File: 367521-07-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-AMino-2,4-dibroMophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMino-2,4-dibroMophenol(367521-07-1)
• EPA Substance Registry System: 5-AMino-2,4-dibroMophenol(367521-07-1)

Safety Data

• Hazardous Substances Data: 367521-07-1(Hazardous Substances Data)

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 621-42-1 meta-hydroxyacetanilide 

Downstream Products

• 607-72-7 5-hydroxy-2-methylquinoline 

Relevant articles and documents

Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives

A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and condensation of ethyl 7-hydroxycoumarin-3-carboxylate with 4,6-dibromo-3-amino phenol. Acylation with acetic anhydride and condensation of coumarin derivatives with 2-hydroxybenzaldehyde yielded the corresponding acetyl derivatives and 4-substituted pyrazole derivatives. Structures of the synthesized compounds were elucidated by spectral methods and elemental analysis. All the prepared derivatives were evaluated for their cytotoxicity against human breast carcinoma cell line (MCF-7). Compound VI showed the least IC50 value in MTT colorimetric assay as compared to that of the standard marketed drug staurosporin.

Method of catalytically synthesizing polybromo-aniline in water phase

The invention discloses a method of catalytically synthesizing polybromo-aniline in a water phase. The method comprises following steps: adding a catalytic amount of a free radical initiator, aniline derivatives, cheap and low-toxic bromine salts, and water into a reactor; carrying out reactions in a photocatalytic reaction instrument under power of 5W at a room temperature; after a while, extracting the reaction product by ethyl acetate, and carrying out recrystallization to obtain polybromo-aniline; wherein the free radical initiator is eosin, sodium persulfate, or potassium persulfate. The power of the incandescent lamp of the photocatalytic reaction instrument is 5W. The free radical initiator and bromine salts are cheap and easily available. The method is an ideal synthesis method of polybromo-aniline. Cheap and low-toxic bromine salts are used to replace liquid bromine. The cheap and easily available free radical initiator is used to replace unstable and explosive hydrogen peroxide. After 4 to 10 hours of reactions under the power of 5W, polybromo-aniline can be synthesized, the yield and the reaction selectivity are high, the byproducts are few, and the post treatment is simple.

SILICONE ATOMS CONTAINING IVACAFTOR ANALOGUES

The present disclosure is directed to disclosed compounds that modulate e.g., address underlying defects in cellular processing of CFTR activity.