367521-36-6

Basic information

• Product Name: (S)-PYRROLIDINE-2-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE
• Synonyms: (S)-PYRROLIDINE-2-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE;(2S)-N-(4-METHOXYPHENYL)-2-PYRROLIDINECARBOXAMIDE;(2S)-N-(4-methoxyphenyl)pyrrolidine-2-carboxamide
• CAS NO: 367521-36-6
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.27
• Mol File: 367521-36-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-PYRROLIDINE-2-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-PYRROLIDINE-2-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE(367521-36-6)
• EPA Substance Registry System: (S)-PYRROLIDINE-2-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE(367521-36-6)

Safety Data

• Hazardous Substances Data: 367521-36-6(Hazardous Substances Data)

Usage

General Description

(S)-PYRROLIDINE-2-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE is a chemical compound that consists of a pyrrolidine carboxylic acid and a 4-methoxy-phenyl group. It is commonly used as a building block in organic synthesis and can be found in various pharmaceuticals and agrochemicals. (S)-PYRROLIDINE-2-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE has been studied for its potential therapeutic applications, particularly in the treatment of neurological disorders and cardiovascular diseases. Its unique structure and properties make it a valuable tool in drug discovery and development, and it continues to be of interest to researchers in the fields of medicinal chemistry and chemical biology.

Upstream product

• 1093957-22-2 tert-Butyl 2-(4-methoxyphenylcarbamoyl)pyrrolidine-1-carboxylate 
• 104-94-9 4-methoxy-aniline 
• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 344-25-2 D-Prolin 
• 147-85-3 L-proline 
• 52815-76-6 1-tert-butyl (2S)-2-[(4-methoxyphenyl)carbamoyl]pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Relevant articles and documents

Synthesis and analgesic evaluation of a series of proline-typed spiro cyclic quaternary ammoniums

A series of proline derivated spirocyclic quaternary ammoniums were synthesized and evaluated via in vivo analgesic activities. Compounds 9a showed the best analgesic effect with 84 % inhibition in mice. These compounds showed only micromolar Ki value by in vitro α7 nAChR binding test, which may indicate the form of active metabolite play a role in their in vitro analgesic activities.

AlMe3-promoted formation of amides from acids and amines

In the presence of AlMe3, amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected se

Use of amino amides derived from proline as chiral ligands in the ruthenium(II)-catalyzed transfer hydrogenation reaction of ketones

We developed an efficient, easily available, and easy to use proline amide-based ruthenium(II) catalysts for the asymmetric hydride transfer reduction of prochiral ketones and e.e.s up to 98.8% have been measured.