36760-19-7

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-3-CHLORO-1H-INDAZOLE is used as a building block for the synthesis of pharmaceutical drugs and agrochemicals due to its versatile chemical structure and potential pharmacological activities.
Used in Research and Development:
5-BROMO-3-CHLORO-1H-INDAZOLE is employed as a research tool for the discovery of new drug candidates and bioactive compounds, leveraging its chemical properties and potential therapeutic effects.
Used in Antibacterial Applications:
5-BROMO-3-CHLORO-1H-INDAZOLE is used as an antibacterial agent, exhibiting potential activity against various bacterial strains, contributing to the development of new antimicrobial drugs.
Used in Antifungal Applications:
5-BROMO-3-CHLORO-1H-INDAZOLE is utilized as an antifungal agent, showing promise in combating fungal infections, and aiding in the creation of novel antifungal medications.
Used in Antiparasitic Applications:
5-BROMO-3-CHLORO-1H-INDAZOLE is applied as an antiparasitic agent, demonstrating potential to treat parasitic infections, and contributing to the advancement of antiparasitic therapeutics.

InChI:InChI=1/C7H4BrClN2/c8-4-1-2-6-5(3-4)7(9)11-10-6/h1-3H,(H,10,11)

Upstream product

• 53857-57-1 5-bromo-1H-indazole 
• 29110-74-5 3-chloroindazole 

Downstream Products

• 1613639-49-8 3-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole 
• 1613639-00-1 (R)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol 
• 1613639-36-3 (R)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide 
• 1613639-37-4 (S)-2-[5-(3-chloro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylacetamide 
• 929617-36-7 tert-butyl 5-bromo-3-chloro-1H-indazole-1-carboxylate 

Relevant academic research and scientific papers

FUSED RING DERIVATIVE AS A2A RECEPTOR INHIBITOR

Disclosed are a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, and an application of the compound or slat in preparation of drugs for treating diseases related to an A2A receptor.

Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one

By the use of 1-chloro-1,2-benziodoxol-3-one, an age-old reagent, the practical and efficient chlorination method is achieved. This hypervalent iodine reagent is amenable not only to the chlorination of nitrogen-containing heterocycles but also to selected classes of arenes, BODIPY dyes, and pharmaceuticals. In addition, the advantages, such as easy preparation and recyclable, air- and moisture-stable, in combination with the success in a gram-scale experiment grant this reagent great potential for industrial application.

SODIUM CHANNEL BLOCKERS

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav 1.7, a preparation method thereof and use thereof. The compound represented by the Formula 1 or a pharmaceutically acceptable salt, hydrate,

Selective Halogenation Using an Aniline Catalyst

Electrophilic halogenation is used to produce a wide variety of halogenated compounds. Previously reported methods have been developed mainly using a reagent-based approach. Unfortunately, a suitable "catalytic" process for halogen transfer reactions has yet to be achieved. In this study, arylamines have been found to generate an N-halo arylamine intermediate, which acts as a highly reactive but selective catalytic electrophilic halogen source. A wide variety of heteroaromatic and aromatic compounds are halogenated using commercially available N-halosuccinimides, for example, NCS, NBS, and NIS, with good to excellent yields and with very high selectivity. In the case of unactivated double bonds, allylic chlorides are obtained under chlorination conditions, whereas bromocyclization occurs for polyolefin. The reactivity of the catalyst can be tuned by varying the electronic properties of the arene moiety of catalyst.

3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt

Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.

KINASE INHIBITORS

A compound having the general structure of Formula (I) or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as immunodeficiencies, cancers, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease.