36768-56-6

Upstream product

• 6336-05-6 6,4'-dichloroflavanone 
• 36768-48-6 (E)-1-(5-Chloro-2-hydroxy-phenyl)-3-(4-chloro-phenyl)-propenone 
• 328925-66-2 1-(5-Chloro-2-hydroxy-phenyl)-3-(4-chloro-phenyl)-propane-1,3-dione 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 36768-48-6 (E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one 
• 873-73-4 4-n-chlorophenylacetylene 
• 635-93-8 5-chlorosalicyclaldehyde 
• 1301225-15-9 C₁₅H₉BrCl₂O₂ 

Downstream Products

• 1132755-71-5 4',6-dichloroflavan 
• 111391-55-0 6-chloro-2-(4-chlorophenyl)-3-hydroxy-4H-chromen-4-one 

Relevant academic research and scientific papers

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coilt P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

A novel one pot route to flavones under dual catalysis, an organo- and a Lewis acid catalyst

Substituted phenylacetylenes react with various o-hydroxy aromatic aldehydes under dual catalysis of piperidine and FeCl3 in refluxing toluene to yield flavones in good to excellent yield. Atmospheric oxygen acts as stoichiometric oxidant in the process. Some of these compounds had been recently reported to show fair insecticidal activity against Spodoptera frugiperda.

Transition-metal-free intramolecular Ullmann-type O-arylation: Synthesis of chromone derivatives

(Chemical Equation Presented) Expect the upexpected: A transition-metal- free approach to access chromone derivatives has been developed. The intramolecular O-arylation of substituted 1-(2-haloaryl)-propane-1,3-diones in DMF in the presence of K2CO3 gave the corresponding target products in good to excellent yields (see scheme; DMF = N,N′- dimethylformamide).

A facile synthesis of flavones catalysed by gallium(III) triflate

Ga(OTf)3 was explored as a novel catalyst for the cyclisation of 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones in nitromethane to flavones with excellent yields.

Mechanically activated solid-state synthesis of flavones by high-speed ball milling

An efficient, mechanically activated solid-state synthesis of flavones from 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones using high-speed ball milling is described. This method has notable advantages in terms of good yield, short reaction time, and neat conditions.

Enantioselective synthesis of chromanes by iridium-catalyzed asymmetric hydrogenation of 4H-chromenes

Iridium complexes of chiral oxazoline-based P,N-ligands proved to be efficient catalysts for the enantioselective hydrogenation of 2-aryl- and 2-alkyl-4H-chromenes. The best results were obtained with a ligand derived from threonine (ThrePHOX), which induced ee values of 95% to >99% in the hydrogenation of 2-methyl-, 2-cyclohexyl- and various 2-aryl-substituted chromenes. Georg Thieme Verlag Stuttgart.

Manganese(III) acetate mediated oxidation of flavanones: A facile synthesis of flavones

Oxidation of flavanones (1a-o) with manganese(III) acetate by heating in acetic acid in presence of perchloric acid afforded exclusively flavones (2a-o) by dehydrogenation in almost quantitative yields. Copyright Taylor & Francis, Inc.

Hypervalent Iodine Oxidation of Flawanones: Convenient and Useful Syntheses of Flavones and IsoFlavones

Hypervalent iodine oxidation of flavanones (1a-g) under a variety of conditions, offering convenient and valuable routes to the syntheses of flavones (2a-g) and isoflavones (3a-g), is described.The course of these oxidation reactions is greatly influenced by the reaction conditions and it is possible to select appropriate conditions for following a desired route (2/3).The mechanistic rationale for these transformations is also discussed.