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N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine hydrochloride, also known as N-Methyl-N-(3-chloropropyl)homoveratrylamine, is a novel class of calcium channel blocker derived from the chemical modification of the phenethylamine structure. It exhibits potent biological activities and has been identified as an impurity in Verapamil, a well-known calcium channel blocker. N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine hydrochloride possesses a unique chemical structure that allows it to interact with specific biological targets, making it a promising candidate for various pharmaceutical applications.

36770-75-9

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36770-75-9 Usage

Uses

Used in Pharmaceutical Industry:
N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine hydrochloride is used as a calcium channel blocker for its ability to modulate the activity of calcium channels, which plays a crucial role in various physiological processes. Its application in this field is aimed at treating conditions such as hypertension, angina, and arrhythmias by regulating the flow of calcium ions through cell membranes, thus affecting the contraction of heart muscles and blood vessel dilation.
Used in Immunotoxin Enhancement:
In the field of cancer research and therapy, N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine hydrochloride has shown the potential to enhance the activity of ricin A-chain immunotoxins (RTA-IT) both in vitro and in vivo. This application is based on its ability to improve the efficacy of these immunotoxins, which are designed to target and destroy cancer cells by inhibiting protein synthesis.
Used as an Impurity in Verapamil:
N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine hydrochloride is also recognized as an impurity in Verapamil (V125000), a widely used calcium channel blocker, adrenergic antagonist, and antiarrhythmic agent (class IV). Its presence in Verapamil may contribute to the overall pharmacological effects of the drug, and understanding its role can help in optimizing the therapeutic potential of Verapamil and related calcium channel blockers.

Check Digit Verification of cas no

The CAS Registry Mumber 36770-75-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,7 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 36770-75:
(7*3)+(6*6)+(5*7)+(4*7)+(3*0)+(2*7)+(1*5)=139
139 % 10 = 9
So 36770-75-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H22ClNO2.ClH/c1-16(9-4-8-15)10-7-12-5-6-13(17-2)14(11-12)18-3;/h5-6,11H,4,7-10H2,1-3H3;1H

36770-75-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amine,hydrochloride

1.2 Other means of identification

Product number -
Other names N-(3-Chloropropyl)-3,4-dimethoxy-N-methylphenethylamine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36770-75-9 SDS

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