36772-64-2Relevant academic research and scientific papers
PHARMACEUTICAL COMPOSITION COMPRISING AZARHODACYANINE COMPOUND AS ACTIVE INGREDIENT
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Page/Page column 42, (2008/06/13)
Disclosed is a pharmaceutical composition, particularly a therapeutic and/or prophylactic pharmaceutical composition having a high therapeutic effect and a high selective toxicity on a protozoan infection with a parasite and also having a life-prolonging effect or the like. A pharmaceutical composition comprising a compound represented by the general formula (1), particularly a therapeutic and/or prophylactic agent for a protozoan infection such as malaria, leishmaniasis, African sleeping sickness, Chagas disease, toxoplasmosis, lymphofilariasis, babesiosis and coccidiosis; and a novel compound to be contained in the pharmaceutical composition or therapeutic and/or prophylactic agent as an active ingredient.
Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity
Takasu, Kiyosei,Inoue, Hiroshi,Kim, Hye-Sook,Suzuki, Makoto,Shishido, Tadao,Wataya, Yusuke,Ihara, Masataka
, p. 995 - 998 (2007/10/03)
The rhodacyanine dye MKT-077 (1), a potent antitumor agent, was found to possess strong in vitro activity against Plasmodium falciparum and a low cytotoxicity. Several new rhodacyanine dyes related to 1, containing a variety of linked heterocyclic moieties, were synthesized, and their antimalarial potencies were evaluated. The synthetic rhodacyanines were found to have EC50 values against P. falciparum in vitro in the range of 4-300 nM. Several compounds in this series have remarkable selective toxicity profiles (> 100).
Structure of rhodanine cyanine dyes, spectroscopy and performance in photographic emulsions
Peng, Zheng-Hong,Zhou, Xiang-Feng,Carroll, Suzanne,Geise, Herman J.,Peng, Bi-Xian,Dommisse, Roger,Esmans, Eddy,Carleer, Robert
, p. 1325 - 1333 (2007/10/03)
The synthesis is reported of eight pyridine-, benzothiazole- and benzimidazole-rhodanine zeromethine merocyanines as bluesensitising dyes (1-8), and of three benzoxazole-rhodanine dimethine merocyanines as green-sensitising dyes (9-11). The compounds were characterised from UV-VIS, mass spectroscopic and NMR data, and the purity of the products was analysed using HPLC. Oxidation potentials were measured using cyclic voltammetry. Ionisation potentials and electron affinities were obtained by semi-empirical MOPAC calculations. The charge-density distributions of the pyridine and benzothiazole rhodanine dyes are in agreement with assignments in NMR spectroscopy. A linear dependence is found between the oxidation potential and ionisation potential, as well as between the reduction potential and electron affinity. Reflection spectra of 6 and 7 coated on photographic emulsions showed J-aggregate absorption at λ= 450 and 465 nm, respectively. The sensitising properties of the merocyanine dyes were evaluated in actual photographic T-grain emulsions.
