36773-26-9Relevant academic research and scientific papers
Synthesis and microbial activity of new 1,4-benzothiazines bearing paracetamol moiety
Patil,Bondge,Bhingolikar,Mane
, p. 1513 - 1515 (2007/10/03)
5-Acetamido-2-hydroxyacetophenone 1 on condensation with aroyl/heteroyl chlorides in pyridine gives esters, 2-acyl-4-acetamidophenyl aroylates / heteroylates 2 which are subjected to B.V. transformation to get 1-aryl-3-[2′-hydroxy-5′-acetamidophenyl]-1,3-propanediones 3. The 1,3-propanediones 3 when condensed with 2-aminobenzenethiols in dimethyl sulfoxide yield the title compounds, 2-[2′-hydroxy-5′-acetamidobenzoyl]-3-aryl/heteryl7- substituted-4H-1,4-benzothiazines 4. The microbial activity of the title compounds has been evaluated.
