36781-65-4 Usage
Uses
Used in Pharmaceutical Industry:
3-Pentynoic acid is used as a chemical reagent for the preparation of small-molecule inhibitors of geranylgeranyltransferase Type I. This enzyme plays a crucial role in the post-translational modification of proteins, which is essential for their function and localization within the cell. Inhibiting this enzyme can have significant therapeutic implications, particularly in the treatment of certain cancers and other diseases.
3-Pentynoic acid is also used in the synthesis of Salinosporamide A, a potent proteasome inhibitor with anti-cancer properties. Proteasomes are cellular complexes responsible for the degradation of damaged or unneeded proteins, and their inhibition can lead to the accumulation of these proteins, ultimately causing cell death. Salinosporamide A has shown promise in the treatment of various cancers, including multiple myeloma and other solid tumors.
In addition to its applications in the pharmaceutical industry, 3-Pentynoic acid may also find use in other fields, such as materials science and chemical research, due to its unique structural features and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 36781-65-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,8 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 36781-65:
(7*3)+(6*6)+(5*7)+(4*8)+(3*1)+(2*6)+(1*5)=144
144 % 10 = 4
So 36781-65-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H6O2/c1-2-3-4-5(6)7/h4H2,1H3,(H,6,7)
36781-65-4Relevant academic research and scientific papers
Synthesis of ω-and (ω - 1)-acetylenic acids from five-, six-, or seven-membered cycloalkanones
Starostin,Ignatenko,Lapitskaya,Pivnitsky,Nikishin
, p. 833 - 837 (2007/10/03)
A convenient method for the synthesis of ω-and (ω - 1)-acetylenic acids involves free-radical oxidative scission of cycloalkanones containing five-, six, or seven-membered cycles to give the corresponding ω-olefinic acids followed by bromination of the latter and subsequent dehydrobromination under the action of alkalis.
