367910-98-3Relevant academic research and scientific papers
Diastereoselectivity during 2-pyridone photo-[4+4] cycloaddition. The tribenzylsilyl protecting group
Sieburth, Scott McN,Madsen-Duggan, Christina B,Zhang, Fangning
, p. 5155 - 5157 (2007/10/03)
The use of a silyloxy group as a stereocontrol element on the most distant carbon of a pyrindinone during intermolecular [4+4] photocycloaddition was tested using silyl groups varying in size (tert-butyldimethylsilyltriisopropylsilyltribenzylsilyl). The ratio of the diastereomeric products was proportional to the size of the silyl group, with the largest, tribenzylsilyl, giving the best ratio of 10:1. The expected stereochemistry was confirmed by X-ray crystallography.
